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July2019
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Literature survey pr…
Literature survey pres. Tom Duivenvoorde
Starts: 12:45 pm
Ends: July 1, 2019 - 1:30 pm
Description:
We are pleased to invite you to attend the PME-Literature survey presentation on:
Monday 1 July 2019, 12h45
Lecture hall E (Robert Hooke)
Mekelweg 2
2628 CD DELFT
12h45 Tom Duivenvoorde, specialisation: MNE
Coaches: Dr. M.K. Ghatkesar, Ir. M. van der Heiden (TNO)
Title: Dissecting the mechanical properties of epithelial cells with Atomic
Force Microscopy
There is a demand for efficient non-invasive early detection methods of diseases in which abnormal behaviour of soft tissues can be detected andmeasured. With the development of micro- and nanoscale characterization tools, the research on cell viability has shifted from in vitro to an organ-on-a-chip environment. This makes it possible to focus more on the state of a single cell or monolayer of cells, understanding how biological systems regulate their biophysical and biomechanical properties.
Among different types of cells in our body, the epithelial cells are of high importance, since they form a barrier layer that regulates the absorption of useful nutrients into the body and restricts the entry of harmful entities like viruses. New technologies such as atomic force microscopy (AFM) are suitable for non-invasive measurement on such cells and they are widely applied for topography imaging of cells and characterizationof their physical properties by nano-indentation. Although AFMhas proven itself in the field of biomechanics, most of the studies performed focus only on bulk elastic properties. However, studies reveal that biological materials exert non-linear viscoelastic behaviour. In particular, the contribution towards the cell’s viscoelastic behaviour from each main sub-cellular and cell-cell interaction component to this day has not been fully understood.
By conducting time-dependent AFM measurements of epithelial cells, and by characterising the viscoelastic properties of the cells at different environmental conditions will shed more light on the contribution of different cellular components. Further correlation of these properties to the metabolic state of the cell, by means of intuitivemechanical models, will help advance the field of non-invasive single cell disease detection.
In this presentation I will give an overview of the epithelial cell in general, its main components, the current state of research, the research question at hand and my future work to solve the research question.
The presentation will be given in English.
13h10 Debate
13h30 End
Attending colloquia is an obligatory part of the curriculum of PME.
The presence of other people who are interested will be appreciated.
We are pleased to invite you to attend the PME-Final MSc presentation on:
Wednesday 10 July 2019, 12h45
Instruction room J
Mekelweg 2
2628 CD DELFT
12h45 Laurens Krijgsman, specialisation: MSD
Coaches: Ir. J.W. Spronck, Dr. A. Hunt
Title: The design of a compact angular drilling device for medical
application
The technology used in health care is one of the fastest developing fields in Precision Engineering. The main focus in this field is on the development of steerable, small dimensioned instruments. Using these, surgeries can be done with minimal damage to the patient, shorter hospital stay and more aesthetical healing.
From the medical field the question arises why medical drilling devices are not developed into smaller, less invasive devices in the last years. The bulkiness of the medical drilling devices currently used is leading to inevitable challenges for surgeons. Sometimes the desired drilling location at the bone is impossible to reach with the devices currently used, alternative methods must be applied, leading to less proper healing, longer hospital stay and revalidation time.
Therefore the goal of this research is to design a compact, angular drilling device for medical application. Experimental research is performed to model, analyse and understand the bone drilling process and a conceptual design for a compact, angular drill is developed.
The presentation will be given in English.
13h05 Debate
13h15 End
Attending colloquia is an obligatory part of the curriculum of PME.
The presence of other people who are interested will be appreciated.
We are pleased to invite you to attend the PME-Final MSc presentation on:
Monday 15 July 2019, 10h30
Instruction room H
Mekelweg 2
2628 CD DELFT
10h30 Chengwei Cai, specialisation: MSD
Coaches: Dr. S.H. Hossein Nia Kani, Dr. N. Saikumar
Title: The optimal sequence of reset controllers
The PID controller is one of the most used controllers in the industry. However, fundamental limitations due to linearity restrict its performances when higher bandwidth, stability, and precision are required simultaneously in today’s high-tech industry. Reset control is a promising nonlinear control strategy which can overcome these limitations. But it also brings new problems.
High order harmonics are introduced into the system because of non-linearity which lead to unwanted dynamics and deterioration of performances. So it is necessary to reduce them as much as possible. It is found that the sequence of different parts of a reset controller has effects on the magnitude of high order harmonics. Through high order sinusoidal input describing functions (HOSIDOFs) tool, the optimal sequence of the open loop in which the magnitude of high order harmonics is minimum is achieved for a general reset controller. The superiority of the suggested sequence in the closed-loop system is validated through both simulation and experiments at a Lorentz-actuated precision positioning stage.
The presentation will be given in English.
10h50 Debate
11h00 End
Attending colloquia is an obligatory part of the curriculum of PME.
The presence of other people who are interested will be appreciated.
We are pleased to invite you to attend the PME-Final MSc presentation on:
Wednesday 17 July 2019, 14h00
Instruction room K
Mekelweg 2
2628 CD DELFT
14h00 Keith Bälz, specialisation: MSD
Coaches: Prof.dr.ir. J.L. Herder, Dr. S.H. Hossein Nia Kani
Title: P(VDF-TrFE-CTFE) actuators with inkjet printed electrodes
The advent of modern smart materials enable methods of sensing and actuation in new form factors, with greater strains and electromechanical performance than previously possible. Smart materials allow for the production of devices such as resonators, micropumps, and artificial muscles with compactness and strains not previously possible with traditional actuators. The manufacture of such devices however presents a significant challenge. Traditional methods of manufacture rely on masking or photolithographic methods which in addition to being both time intensive and costly, require special machinery to achieve . As an alternative, inkjet printing offers an additive manufacturing method for the production of thin films. This thesis will describe the manufacture of P(VDF-TrFE-CTFE) actuators with inkjet printed carbon black electrodes. Produced actuators achieve 206 𝜇m steady state deflections at 300 V and 3 mm at resonance. This shows an 89.4% improvement in strain per volt compared to similar inkjet manufactured P(VDF-TrFE) actuators in literature.
The presentation will be given in English.
14h20 Debate
14h30 End
Attending colloquia is an obligatory part of the curriculum of PME.
The presence of other people who are interested will be appreciated.
We are pleased to invite you to attend the PME-Final MSc presentation on:
Friday 19 July 2019, 12h15
Instruction room H
Mekelweg 2
2628 CD DELFT
12h15 Johan Schonebaum, specialisation: DMN
Coaches: Dr. F. Alijani, Dr. G. Radaelli
Title: The design of a resonant, compliant, monolithic running robot at
insect scale
Over the past decade, there has been an increasing interest in insect-like, autonomous running robots. Due to their small size, low mass and other properties, they have numerous potential applications. These include exploration of hazardous environments like collapsed or damaged buildings, natural disaster sites, debris and war zones. The main challenges associated with designing these robots are the energy management, actuation and manufacturing. To overcome these challenges we propose to make use of designed resonance and a fully monolithic design. We expect that these solutions can improve insect scale running robots in terms of (i) efficiency, (ii) actuation complexity, (iii) manufacturing tolerance, (iv) suitability for rapid prototyping and large number reproduction and (v) miniaturization opportunities.
The design of FARbot, a Frequency Actuated Resonant robot is presented, that uses resonance to increase its stride length and is fully monolithic. A novel design methodology is discussed to systematically obtain a compliant mechanism that resonates in a desired motion and at a desired frequency. Two prototype iterations of FARbot are produced. Although it can not run, it does proof that the desired resonance behaviour is obtained and that the monolithic design decreases production time and complexity significantly as compared to current state of the art.
The presentation will be given in English.
12h35 Debate
12h45 End
Attending colloquia is an obligatory part of the curriculum of PME.
The presence of other people who are interested will be appreciated.
Title: Cryo sample transfer solution of correlated light and electron
microscopy
The Nobel Prize in Chemistry in 2017 went to the development of cryo-electron microscopy, which contributed to the discovery of new cells and viruses, the diagnosis of unknown diseases, the mapping of human genomes and the manufacturing of semiconductors. Cryo Correlative light-electron microscopy (Cryo-CLEM) is the combination of using fluorescence microscopy and cryo-electron microscopy to image cryo-immobilized bio-samples. These samples (at a temperature lower than −165ᵒC) require critical conditions in preparation and preservation to prevent contamination and heating which have a strong negative influence on the imaging results. In the current sample transfer workflow, almost 90% of the samples transferred end up being wasted due to the non-ideal protection and transfer gap. Therefore, an integrated high-vacuum sample transfer system which fits the interfaces of CLEM devices and actively protects the samples from heating and contamination in transfer has been designed to conquer the problems, ensure better imaging results and increase the process yield. COMSOL simulations on its thermal and mechanical behaviors have been carried out to theoretically verify and iterate the design. The new transfer system provides a cheaper, faster, easier, more contamination-free, more temperature-stable, more user-friendly workflow that can increase the yield of sample transfer from 10% to 90%.
The presentation will be given in English.
10h05 Debate
10h15 End
Attending colloquia is an obligatory part of the curriculum of PME.
The presence of other people who are interested will be appreciated.
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